GHK-Cu
Also known as: Copper Peptide, GHK-Copper
A copper-binding tripeptide with extensive tissue regeneration properties.
Overview
GHK-Cu is a naturally occurring copper complex of the tripeptide Gly-His-Lys. Found in plasma and extracellular matrix, it declines with age and has broad tissue remodeling effects.
Mechanism of Action
Modulates gene expression affecting collagen synthesis, wound healing, immune function, and antioxidant capacity. The copper ion is essential for biological activity. Resets gene expression toward a healthier state.
Pharmacokinetics
Distributed to skin and tissues. Can be applied topically or injected. Copper delivery enhances local enzymatic activity.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Topical
1-2% cream
1-2x daily
Ongoing
Skincare application
Subcutaneous
1-2 mg
Once daily
4-8 weeks
Systemic anti-aging protocol
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Stimulates collagen and glycosaminoglycan synthesis
- 2Promotes wound healing and tissue remodeling
- 3Activates stem cells and tissue regeneration
- 4Gene expression studies show broad anti-aging effects
Side Effects & Contraindications
Reported Side Effects
- Skin irritation (topical)
- Generally well-tolerated
Contraindications
- Wilson's disease
- Copper sensitivity
Safety Considerations
Well-tolerated. Topical copper peptides widely used in skincare. Systemic dosing less characterized.
Storage Requirements
Store protected from light. Reconstituted at 2-8C.
Scientific References
- 1