BPC-157
Also known as: Body Protection Compound-157, Pentadecapeptide BPC 157, PL 14736
A synthetic pentadecapeptide derived from human gastric juice with remarkable tissue-healing properties.
Overview
BPC-157 is a synthetic 15 amino acid peptide derived from a portion of the human gastric protein BPC. First isolated from human gastric juice, this peptide has demonstrated significant cytoprotective and healing properties across multiple tissue types in preclinical studies.
Mechanism of Action
BPC-157 upregulates growth hormone receptor expression and modulates the nitric oxide system, promoting angiogenesis through VEGF upregulation. It promotes the FAK-paxillin pathway crucial for cell migration and wound healing.
Pharmacokinetics
BPC-157 demonstrates remarkable stability in gastric juice, maintaining activity for over 24 hours. Shows activity at nanogram to microgram doses.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Systemic Protocol
250-500 mcg
1-2 times daily
4-12 weeks
Subcutaneous for systemic healing
Local Injection
200-300 mcg
Once daily
2-4 weeks
Near injury site for localized effect
Oral Protocol
500 mcg
Twice daily
4-8 weeks
For GI-specific applications
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Accelerated healing of transected Achilles tendons in rat models by 72%
- 2Demonstrated cytoprotection against NSAID-induced gastric lesions
- 3Promoted angiogenesis and granulation tissue formation
- 4Showed neuroprotective effects in traumatic brain injury models
Side Effects & Contraindications
Reported Side Effects
- Injection site irritation (rare)
- Generally well-tolerated
Contraindications
- Active malignancy (theoretical)
- Pregnancy (insufficient data)
Safety Considerations
No significant toxicity observed in animal studies at doses up to 10 mg/kg. Human safety data is limited.
Storage Requirements
Store lyophilized at -20C. Reconstituted stable at 2-8C for 14 days.
Scientific References
- 1Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract
Sikiric P, et al.
Current Pharmaceutical Design, 2018 | DOI: 10.2174/1381612824666180718095353