SNAP-8
Also known as: Acetyl Octapeptide-3
A topical peptide that reduces expression wrinkles through muscle relaxation.
Overview
SNAP-8 is an octapeptide that mimics the N-terminus of SNAP-25, a protein involved in neuromuscular junction signaling. It provides a topical alternative to botulinum toxin for expression lines.
Mechanism of Action
Competes with SNAP-25 in the SNARE complex formation, reducing acetylcholine release and muscle contraction. Results in relaxation of facial muscles and reduced wrinkle depth.
Pharmacokinetics
Topical penetration to dermal layers. Local activity at neuromuscular junction. No systemic effects.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Topical
3-10% in formulation
1-2x daily
Ongoing
Apply to expression line areas
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Reduced wrinkle depth by up to 63% in clinical studies
- 2Comparable efficacy to other anti-wrinkle peptides
- 3Safe for long-term topical use
- 4Works synergistically with other cosmetic peptides
Side Effects & Contraindications
Reported Side Effects
- Rare skin irritation
Contraindications
- None known for topical use
Safety Considerations
Excellent safety for topical use. Not for injection. Avoid eye area.
Storage Requirements
Store at room temperature
Scientific References
- 1