MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c
A mitochondrial-derived peptide that regulates metabolism and exercise response.
Overview
MOTS-c is a peptide encoded within the mitochondrial genome, representing a new class of signaling molecules. It regulates metabolic homeostasis and has been called an 'exercise mimetic'.
Mechanism of Action
Activates AMPK pathway, promoting glucose uptake and fatty acid oxidation. Translocates to nucleus to regulate gene expression. Enhances cellular stress resistance.
Pharmacokinetics
Levels decline with age. Exogenous administration shows systemic distribution. Mechanism of cellular entry under investigation.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
5-10 mg
3-5x weekly
4-8 weeks
Based on preclinical extrapolation
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Improved glucose tolerance in mouse obesity models
- 2Enhanced exercise capacity and endurance
- 3Levels correlate with metabolic health in humans
- 4May mediate some benefits of exercise
Side Effects & Contraindications
Reported Side Effects
- Limited data available
Contraindications
- Pregnancy (unknown effects)
Safety Considerations
Limited human safety data. Preclinical studies suggest good tolerability.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1