NAD+ Peptides
Also known as: NAD+, Nicotinamide Adenine Dinucleotide
Peptides and molecules that support cellular NAD+ levels for metabolic health.
Overview
NAD+ is a critical coenzyme for cellular energy metabolism and sirtuin activity. Levels decline with age, and restoration through precursors and peptides is a key longevity strategy.
Mechanism of Action
NAD+ serves as electron carrier in metabolism and substrate for sirtuins (SIRT1-7), PARPs, and CD38. Supporting NAD+ levels enhances mitochondrial function and cellular repair.
Pharmacokinetics
Direct NAD+ has limited bioavailability; precursors (NMN, NR) and injection routes preferred for elevation.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
IV Protocol
250-500 mg
Daily
5-10 days
IV infusion over 2-4 hours
Subcutaneous
50-100 mg
Daily
4-8 weeks
Self-administered maintenance
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1NAD+ decline correlates with aging hallmarks
- 2Restoration improves mitochondrial function in aged mice
- 3Sirtuin activation linked to longevity pathways
- 4Clinical trials ongoing for various indications
Side Effects & Contraindications
Reported Side Effects
- Flushing (IV)
- Nausea
- Chest tightness (IV)
Contraindications
- Active cancer (theoretical)
Safety Considerations
Generally well-tolerated. IV NAD+ may cause flushing, nausea during infusion.
Storage Requirements
Store at 2-8C, protected from light
Scientific References
- 1