DSIP
Also known as: Delta Sleep-Inducing Peptide
A neuropeptide that promotes delta wave sleep and stress resilience.
Overview
DSIP is a neuropeptide first isolated from rabbit brain during induced sleep. It promotes slow-wave (delta) sleep and has stress-protective and neuromodulatory effects.
Mechanism of Action
Modulates sleep architecture by enhancing slow-wave sleep. Acts on multiple neurotransmitter systems including GABA, serotonin, and opioid pathways. Normalizes cortisol patterns.
Pharmacokinetics
Crosses blood-brain barrier. Short plasma half-life (~15 minutes) but effects persist. May accumulate with repeated dosing.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Sleep Support
100-200 mcg
Before bed
2-4 weeks
Start low, assess response
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Increased delta wave sleep in human studies
- 2Normalized cortisol rhythm
- 3Analgesic effects in chronic pain
- 4Reduced withdrawal symptoms in addiction
Side Effects & Contraindications
Reported Side Effects
- Drowsiness
- Vivid dreams
- Headache (rare)
Contraindications
- Daytime alertness-critical jobs
Safety Considerations
Generally well-tolerated. May cause vivid dreams. Daytime drowsiness possible.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1