NAD+
Also known as: Nicotinamide Adenine Dinucleotide, NAD, Coenzyme
An essential coenzyme for cellular energy and longevity pathways.
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells. It plays essential roles in energy metabolism, DNA repair, and sirtuin activation. NAD+ levels decline with age, and supplementation or IV infusion is being researched for anti-aging, neuroprotection, and addiction treatment.
Mechanism of Action
Functions as electron carrier in redox reactions for ATP production. Required for sirtuin activity (SIRT1-7) which regulate aging processes. Essential for PARP-mediated DNA repair. Declines significantly with age.
Pharmacokinetics
IV infusion provides direct NAD+ delivery. Oral precursors (NMN, NR) are also used. Half-life of circulating NAD+ is short; cellular pools are regulated.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
IV Infusion
250-500 mg
1-4x weekly
Series of 4-10
Infuse over 2-4 hours to reduce side effects
High Dose IV
750-1000 mg
Weekly
4-8 sessions
For addiction or severe fatigue
Oral NMN/NR
250-1000 mg
Daily
Ongoing
NAD+ precursor supplements
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1NAD+ levels decline 50%+ with age
- 2Sirtuin activation requires NAD+
- 3IV infusion used for addiction and fatigue
- 4Precursors (NMN, NR) can raise NAD+ levels
Side Effects & Contraindications
Reported Side Effects
- Flushing (IV)
- Nausea
- Chest tightness (IV)
- Headache
- Fatigue during infusion
Contraindications
- Active cancer (theoretical concern)
- Severe cardiovascular disease (for IV)
Safety Considerations
IV infusion can cause flushing, nausea, chest tightness during administration. Start slow. Generally safe but expensive. Oral precursors are alternative.
Storage Requirements
Refrigerate solutions, protect from light
Scientific References
- 1