Orexin B
Also known as: Hypocretin-2, OX-B, HCRT-2
A neuropeptide related to Orexin A, regulating sleep, arousal, and metabolism.
Overview
Orexin B (Hypocretin-2) is a 28-amino acid neuropeptide closely related to Orexin A. It is produced in the same hypothalamic neurons and plays similar roles in regulating sleep-wake cycles, arousal, and feeding behavior. It has slightly different receptor selectivity compared to Orexin A.
Mechanism of Action
Primarily activates OX2R (orexin receptor 2) with less activity at OX1R compared to Orexin A. Promotes wakefulness and arousal. Regulates feeding behavior and energy homeostasis.
Pharmacokinetics
Poor BBB penetration peripherally. Short half-life. Research typically uses intranasal or central delivery.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
10-50 mcg
As needed
Acute studies
Experimental only
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Co-released with Orexin A from hypothalamic neurons
- 2More selective for OX2R than Orexin A
- 3Involved in sleep-wake regulation
- 4Deficiency contributes to narcolepsy
Side Effects & Contraindications
Reported Side Effects
- Anxiety
- Increased alertness
- Appetite changes
- Cardiovascular effects
Contraindications
- Anxiety disorders
- Insomnia
- Cardiovascular disease
Safety Considerations
Research compound. Limited safety data. May cause overstimulation, anxiety, or cardiovascular effects.
Storage Requirements
Store at -20°C
Scientific References
- 1