Humanin
Also known as: HN, HNG
A mitochondrial-derived peptide with cytoprotective and neuroprotective properties.
Overview
Humanin is a 24 amino acid peptide encoded in the mitochondrial genome. Discovered for its ability to protect neurons, it has broad cytoprotective effects across multiple organ systems.
Mechanism of Action
Binds to BAX to prevent apoptosis. Activates pro-survival signaling through STAT3 and ERK pathways. Enhances insulin sensitivity through IGF-1BP3 interaction.
Pharmacokinetics
Circulating levels decline with age. Modified versions (HNG, HN17) have enhanced potency and stability.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
1-4 mg
Daily
4-8 weeks
Based on preclinical data
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Protected neurons against amyloid-beta toxicity
- 2Reduced myocardial infarct size in animal models
- 3Improved glucose tolerance and insulin sensitivity
- 4Circulating levels inversely correlate with age and disease
Side Effects & Contraindications
Reported Side Effects
- Limited data
Contraindications
- Unknown
Safety Considerations
Generally well-tolerated in preclinical studies. Human data limited.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1