HMG
Also known as: Human Menopausal Gonadotropin, Menotropin, Menopur
A combination of FSH and LH for fertility treatment.
Overview
HMG is a purified preparation containing both FSH and LH activity, originally derived from menopausal women's urine. Used to stimulate gonadal function in both sexes.
Mechanism of Action
FSH component stimulates follicle/sperm development. LH component supports steroidogenesis and final maturation. Combined action mimics natural gonadotropin function.
Pharmacokinetics
Half-life approximately 24 hours. Cumulative effects with daily dosing.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Female Fertility
75-150 IU
Daily
7-12 days
Monitor follicle development
Male Infertility
75-150 IU
3x weekly
3-6 months
Combined with HCG
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Effective for ovulation induction
- 2Used in IVF stimulation protocols
- 3Can restore spermatogenesis in hypogonadal men
- 4Well-established fertility treatment
Side Effects & Contraindications
Reported Side Effects
- OHSS (females)
- Injection site reactions
- Multiple pregnancy
- Gynecomastia (males)
Contraindications
- Ovarian cysts
- Unexplained uterine bleeding
- Sex hormone-dependent tumors
Safety Considerations
Risk of ovarian hyperstimulation syndrome (OHSS) in females. Multiple pregnancy risk. Monitor with ultrasound and hormone levels.
Storage Requirements
Refrigerate at 2-8C
Scientific References
- 1HMG in assisted reproduction
Human Reproduction, 2003