Triptorelin
Also known as: Decapeptyl, Trelstar, GnRH Agonist
A long-acting GnRH agonist for hormone regulation and fertility.
Overview
Triptorelin is a synthetic GnRH agonist with much longer duration than natural GnRH. Initial stimulation followed by receptor downregulation makes it useful for both fertility and hormone suppression.
Mechanism of Action
Initially stimulates LH/FSH release (flare effect), then causes receptor downregulation leading to hormone suppression. Used for fertility stimulation or chemical castration depending on protocol.
Pharmacokinetics
Depot formulations provide 1-6 month duration. Initial hormone spike followed by suppression.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Prostate Cancer
3.75 mg
Monthly
Ongoing
Or 11.25mg every 3 months
Fertility
0.1 mg
Daily SC
Protocol-dependent
Short-acting for controlled stimulation
Research Areas
Key Research Findings
- 1Effective for prostate cancer hormone suppression
- 2Used in fertility protocols for controlled stimulation
- 3Treats endometriosis through hormone suppression
- 4Manages precocious puberty
Side Effects & Contraindications
Reported Side Effects
- Hot flashes
- Decreased libido
- Initial flare
- Bone density loss (long-term)
Contraindications
- Pregnancy
- Undiagnosed vaginal bleeding
Safety Considerations
Initial flare may temporarily worsen hormone-dependent conditions. Hot flashes and mood changes common with suppression.
Storage Requirements
Store at room temperature
Scientific References
- 1Triptorelin in prostate cancer
European Urology, 2006