HCG
Also known as: Human Chorionic Gonadotropin, Pregnyl, Novarel
A glycoprotein hormone that mimics LH for gonadal stimulation.
Overview
HCG is a glycoprotein hormone produced during pregnancy that shares structural similarity with LH. It directly stimulates gonadal function and is used for fertility, hypogonadism, and maintaining testicular function.
Mechanism of Action
Binds and activates LH receptors on Leydig cells (testosterone production) and ovarian cells (ovulation). Bypasses hypothalamic-pituitary axis to directly stimulate gonads.
Pharmacokinetics
Half-life 24-36 hours. Peak levels 6-12 hours post-injection. Effects persist for days.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
TRT Support
250-500 IU
2-3x weekly
Ongoing
Maintains testicular function
Fertility
1000-2000 IU
2-3x weekly
3-6 months
Combined with other fertility treatments
Ovulation Trigger
5000-10000 IU
Single dose
Once
36 hours before egg retrieval
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Approved for infertility and hypogonadism
- 2Maintains testicular size and function during TRT
- 3Triggers ovulation in fertility protocols
- 4Stimulates testosterone production directly
Side Effects & Contraindications
Reported Side Effects
- Gynecomastia
- Water retention
- Mood changes
- Injection site pain
Contraindications
- Prostate cancer
- Hormone-sensitive cancers
- Precocious puberty
Safety Considerations
May cause gynecomastia at high doses due to estrogen conversion. OHSS risk in females. Monitor estrogen levels.
Storage Requirements
Refrigerate at 2-8C after reconstitution
Scientific References
- 1