Gonadorelin
Also known as: GnRH, LHRH, Factrel
The natural gonadotropin-releasing hormone for fertility and hormone testing.
Overview
Gonadorelin is synthetic GnRH identical to the endogenous hypothalamic hormone. It stimulates pituitary release of LH and FSH, used for fertility treatment and diagnostic testing.
Mechanism of Action
Binds GnRH receptors on pituitary gonadotrophs, stimulating LH and FSH release. Pulsatile administration maintains gonadal function; continuous can suppress it.
Pharmacokinetics
Very short half-life (2-4 minutes). Must be given in pulses to maintain efficacy. Rapid pituitary response.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Fertility
75-150 mcg
Every 90-120 min via pump
Until ovulation/conception
Pulsatile pump required
TRT Support
100-500 mcg
2-3x weekly
Ongoing
Maintains testicular function
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Effective for hypothalamic amenorrhea
- 2Used in fertility treatment protocols
- 3Diagnostic for pituitary reserve testing
- 4Maintains testicular function during TRT
Side Effects & Contraindications
Reported Side Effects
- Headache
- Flushing
- Nausea
- Injection site reactions
Contraindications
- Pregnancy
- Hormone-sensitive cancers
- Pituitary tumor
Safety Considerations
Well-tolerated. Ovarian hyperstimulation possible in fertility use. Monitor hormone levels.
Storage Requirements
Store at 2-8C
Scientific References
- 1