Kisspeptin
Also known as: Kisspeptin-10, Metastin
A neuropeptide that regulates the hypothalamic-pituitary-gonadal axis.
Overview
Kisspeptin is a neuropeptide crucial for puberty initiation and reproductive function. It stimulates GnRH release, making it a key regulator of the entire reproductive hormone cascade.
Mechanism of Action
Binds KISS1R (GPR54) on GnRH neurons in hypothalamus, triggering GnRH release. This stimulates LH and FSH secretion, increasing gonadal hormone production.
Pharmacokinetics
Very short half-life (~30 minutes). Pulsatile administration may be needed to avoid desensitization.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
1-10 nmol/kg
Variable
Study-dependent
Typically IV for research; pulsatile may be needed
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Potently stimulates LH and FSH release
- 2May be useful for IVF protocols
- 3Being studied for hypogonadotropic hypogonadism
- 4Potential male infertility treatment
Side Effects & Contraindications
Reported Side Effects
- Flushing
- Headache
- Nausea
Contraindications
- Pregnancy
- Hormone-sensitive cancers
Safety Considerations
Generally well-tolerated in studies. May cause hormone fluctuations. Not for use during pregnancy.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1