TB-500
Also known as: Thymosin Beta-4, TB4
A synthetic fragment of thymosin beta-4 that promotes tissue repair, cell migration, and angiogenesis.
Overview
TB-500 is a synthetic version of thymosin beta-4, a 43-amino acid peptide found in all tissues except red blood cells. It plays critical roles in tissue repair, cell migration, and blood vessel formation.
Mechanism of Action
TB-500 sequesters G-actin and promotes F-actin formation, essential for cell motility. Upregulates actin and enhances cell migration to injury sites. Promotes angiogenesis and reduces inflammation.
Pharmacokinetics
Distributed systemically with preferential accumulation at injury sites. Half-life approximately 2 hours but effects persist longer.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Loading
2-2.5 mg
Twice weekly
4-6 weeks
Initial loading phase
Maintenance
2 mg
Once weekly
4-8 weeks
Maintenance phase
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Promoted cardiac repair in mouse myocardial infarction models
- 2Enhanced wound healing and reduced scar formation
- 3Demonstrated hair growth stimulation in preclinical studies
- 4Neuroprotective effects in stroke models
Side Effects & Contraindications
Reported Side Effects
- Injection site reactions
- Headache (rare)
- Lethargy (rare)
Contraindications
- Active cancer
- Pregnancy
Safety Considerations
Generally well-tolerated. Theoretical concerns about tumor promotion, though not demonstrated.
Storage Requirements
Store lyophilized at -20C. Reconstituted stable at 2-8C for 14 days.
Scientific References
- 1