PTD-DBM
Also known as: Protein Transduction Domain-DBM, Bone Formation Peptide
A cell-penetrating peptide for bone regeneration and fracture healing.
Overview
PTD-DBM is a synthetic peptide combining a protein transduction domain with a BMP-binding sequence. It enhances bone morphogenetic protein (BMP) signaling to promote bone formation and healing. It shows promise for fracture repair and bone regeneration.
Mechanism of Action
The PTD allows cell penetration while the DBM (demineralized bone matrix-binding) sequence enhances BMP-2 signaling. Promotes osteoblast differentiation and bone formation. May reduce the BMP dose needed for bone healing.
Pharmacokinetics
Local application to bone defects. Cell-penetrating peptide allows tissue uptake.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Bone Healing Research
Variable
Single or repeated local application
Until healing
Applied to fracture or defect site
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Enhanced bone formation in animal models
- 2Synergizes with BMPs for healing
- 3Cell-penetrating delivery improves uptake
- 4Potential to reduce BMP doses needed
Side Effects & Contraindications
Reported Side Effects
- Local reactions
- Limited systemic data
Contraindications
- Active bone infection
- Malignancy at site
Safety Considerations
Research compound. Local application. Limited systemic data. Used in orthopedic research settings.
Storage Requirements
Store at -20°C
Scientific References
- 1