PNC-27
Also known as: P53 Peptide, Cancer-Targeting Peptide
A p53-derived peptide that selectively targets and destroys cancer cells.
Overview
PNC-27 is a synthetic peptide containing a fragment of p53 tumor suppressor protein linked to a cell-penetrating sequence. It selectively binds to HDM-2 protein overexpressed on cancer cell membranes, causing membrane disruption and cancer cell death while sparing normal cells.
Mechanism of Action
Contains p53 residues 12-26 linked to penetratin. Binds HDM-2 (MDM2) on cancer cell membranes (not present on normal cells). Causes membrane pore formation and necrosis in cancer cells. Spares normal cells lacking surface HDM-2.
Pharmacokinetics
Peptide with targeted delivery to cancer cells. Research uses local or systemic injection. Metabolized by peptidases.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research Only
Variable
Variable
Variable
Experimental cancer research only
Research Areas
Key Research Findings
- 1Selectively kills cancer cells in vitro
- 2Targets HDM-2 on cancer cell surface
- 3Spares normal cells
- 4Active against multiple cancer types in studies
Side Effects & Contraindications
Reported Side Effects
- Local injection reactions
- Limited data
Contraindications
- Should not be used as primary cancer treatment
Safety Considerations
Research compound. Not FDA approved for cancer treatment. Do not use as cancer therapy outside clinical trials. Preclinical data only.
Storage Requirements
Store at -20°C
Scientific References
- 1