Dihexa
Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A potent cognitive enhancer derived from angiotensin IV.
Overview
Dihexa is a small peptide analog of angiotensin IV that is reportedly millions of times more potent than BDNF at promoting neuronal connectivity. It was developed for cognitive disorders.
Mechanism of Action
Activates hepatocyte growth factor (HGF) / c-Met pathway, dramatically enhancing synaptic connectivity. Promotes dendritic spine formation and memory consolidation.
Pharmacokinetics
Highly brain-penetrant. Oral bioavailability claimed. Long-lasting effects on synaptic plasticity.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
10-20 mg
Once daily
2-4 weeks
Sublingual or oral; extreme caution advised
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Restored cognitive function in animal dementia models
- 2Enhanced synaptic connectivity at picomolar concentrations
- 3Oral activity claimed (unusual for peptides)
- 4Long-lasting cognitive improvements after treatment cessation
Side Effects & Contraindications
Reported Side Effects
- Unknown - limited data
Contraindications
- Unknown - use extreme caution
Safety Considerations
Very limited safety data. Extreme potency raises concerns. Not approved for human use.
Storage Requirements
Store at -20C
Scientific References
- 1