Glutathione
Also known as: GSH, L-Glutathione, Reduced Glutathione, Master Antioxidant
The body's master antioxidant for detoxification, immune function, and cellular protection.
Overview
Glutathione is a tripeptide (glutamate-cysteine-glycine) that serves as the body's primary intracellular antioxidant. It plays critical roles in detoxification, immune function, and protecting cells from oxidative damage. Levels decline with age and illness, making supplementation popular for anti-aging and detox.
Mechanism of Action
Directly neutralizes free radicals and reactive oxygen species. Conjugates with toxins for excretion via glutathione-S-transferase. Regenerates other antioxidants (vitamins C, E). Essential for immune cell function.
Pharmacokinetics
Poor oral bioavailability (broken down in gut). IV/IM provides direct delivery. Liposomal forms improve oral absorption.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
IV Push
600-2000 mg
1-2x weekly
Series of 8-10
Pushed slowly
Oral Liposomal
250-500 mg
Daily
Ongoing
Liposomal form preferred
Nebulized
200 mg
1-2x daily
As needed
For respiratory conditions
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Master antioxidant and detoxifier
- 2IV form popular for skin lightening
- 3Supports liver detoxification pathways
- 4Declines significantly with age
Side Effects & Contraindications
Reported Side Effects
- Zinc depletion (chronic use)
- Bloating (oral)
- Rare allergic reactions (IV)
Contraindications
- Asthma (nebulized may trigger)
- Sulfite sensitivity
Safety Considerations
Generally safe. IV can cause rare reactions. May lower zinc levels with chronic high doses. Skin lightening use controversial.
Storage Requirements
Refrigerate solutions, protect from light
Scientific References
- 1