P21
Also known as: P021, Peptide 021
A CNTF-derived peptide for neurogenesis and cognitive support.
Overview
P21 is a small peptide derived from ciliary neurotrophic factor (CNTF) that promotes neurogenesis and has shown benefits in Alzheimer's disease models.
Mechanism of Action
Stimulates neurogenesis in the dentate gyrus of the hippocampus. Inhibits leukemia inhibitory factor (LIF) signaling to reduce neuroinflammation. Promotes BDNF expression.
Pharmacokinetics
Can be administered intranasally or peripherally with CNS effects. Mechanism of brain penetration under investigation.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
75-150 mcg/kg
Once daily
4-8 weeks
Based on animal studies
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Increased hippocampal neurogenesis in aged mice
- 2Improved memory in Alzheimer's mouse models
- 3Reduced tau pathology
- 4Enhanced synaptic plasticity
Side Effects & Contraindications
Reported Side Effects
- Limited data
Contraindications
- Unknown
Safety Considerations
Limited human safety data. Preclinical studies suggest good tolerability.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1