Kisspeptin-10
Also known as: Kisspeptin, KP-10, Metastin Fragment
A fragment of kisspeptin that stimulates GnRH release for reproductive function.
Overview
Kisspeptin-10 is a decapeptide fragment of the full kisspeptin protein that plays a critical role in reproductive function. It stimulates GnRH release from the hypothalamus, triggering the HPG axis. It is being researched for infertility, hypogonadism, and as an alternative to GnRH agonists.
Mechanism of Action
Binds to KISS1R (GPR54) on GnRH neurons, stimulating GnRH release. This triggers pituitary LH and FSH secretion, ultimately increasing sex hormone production. Acts as master regulator of reproductive axis.
Pharmacokinetics
Very short half-life (~30 minutes). IV or SubQ administration. Rapid effects on LH pulse.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
LH Stimulation
1-10 nmol/kg
Single or repeated doses
Acute use
Research protocols
IVF Trigger
Variable
Single dose
Once
Alternative to hCG trigger
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Master regulator of GnRH release
- 2Stimulates LH pulse within minutes
- 3Alternative to GnRH for IVF trigger
- 4Potential for hypogonadism treatment
Side Effects & Contraindications
Reported Side Effects
- Hot flashes
- Headache
- Nausea
- Abdominal discomfort
Contraindications
- Pregnancy
- Sex hormone-sensitive cancers
Safety Considerations
Research compound for most uses. Short half-life limits practical application. Being studied for IVF protocols.
Storage Requirements
Store at -20C
Scientific References
- 1