FOXO4
Also known as: Forkhead Box O4, FOXO4 Peptide
The native FOXO4 peptide sequence involved in cellular senescence regulation.
Overview
FOXO4 is a forkhead transcription factor involved in cellular stress responses and senescence. The native peptide is studied for its role in the FOXO4-p53 interaction that protects senescent cells. Understanding this interaction led to the development of FOXO4-DRI as a senolytic agent.
Mechanism of Action
FOXO4 binds to p53 in senescent cells, sequestering it in the nucleus and preventing apoptosis. This interaction is what keeps senescent cells alive. Native FOXO4 peptides are used to study this mechanism.
Pharmacokinetics
Native L-amino acid peptide with shorter half-life than DRI version. Susceptible to proteolytic degradation.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research
Variable
Variable
Variable
Mechanistic studies
Research Areas
Key Research Findings
- 1Key regulator of senescent cell survival
- 2Interacts with p53 to prevent apoptosis
- 3Research tool for understanding senescence
- 4Led to development of FOXO4-DRI senolytic
Side Effects & Contraindications
Reported Side Effects
- Unknown - research compound
Contraindications
- Research use only
Safety Considerations
Research compound. Native version less stable than DRI. Used primarily for mechanistic studies.
Storage Requirements
Store at -20C
Scientific References
- 1