GHRP-6

Also known as: Growth Hormone Releasing Peptide-6, GHRP-6 Acetate

A growth hormone secretagogue known for strong appetite stimulation.

Overview

GHRP-6 is a synthetic hexapeptide that strongly stimulates GH release and appetite. It was one of the first GHRPs developed and remains widely used.

Mechanism of Action

Activates ghrelin receptors, triggering GH release from the pituitary. Strong appetite stimulation through hypothalamic ghrelin pathways. Also has cytoprotective effects.

Pharmacokinetics

Rapid onset with peak GH at 15-30 minutes. Half-life approximately 20 minutes. Strong hunger response within minutes.

Dosing Protocols

Note: These are research protocols from literature. This is not medical advice.

1

Standard

Dose

100-200 mcg

Frequency

2-3x daily

Duration

8-12 weeks

Expect increased hunger

Stacking Recommendations

Peptides that may be combined based on complementary mechanisms in research settings.

Rationale: Synergistic GH

Synergy: Strong GHRH + GHRP combination

Rationale: GI protection

Synergy: Enhanced gut health and GH

Research Areas

GH DeficiencyAppetite StimulationMuscle GrowthCytoprotection

Key Research Findings

  • 1Robust GH release comparable to GHRP-2
  • 2Strong appetite stimulation (useful in wasting conditions)
  • 3Cytoprotective effects on heart and stomach
  • 4May increase cortisol and prolactin

Side Effects & Contraindications

Reported Side Effects

  • Intense hunger
  • Water retention
  • Cortisol elevation

Contraindications

  • Obesity (relative)
  • Active malignancy

Safety Considerations

Strong appetite increase may be unwanted. Affects cortisol and prolactin more than ipamorelin.

Storage Requirements

Store lyophilized at -20C

Scientific References

Quick Reference

Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular Weight
873 g/mol
Half-Life
~20 minutes
Bioavailability
High (SC)
Research Stage
clinical phase 2
Administration
Subcutaneous injection