Ghrelin
Also known as: Hunger Hormone, Lenomorelin, Growth Hormone Releasing Peptide
The hunger hormone produced in the stomach that regulates appetite and GI motility.
Overview
Ghrelin is a 28-amino acid peptide hormone primarily produced by cells in the stomach lining. Known as the 'hunger hormone,' it plays crucial roles in appetite regulation, gastric motility, and growth hormone release. It is being researched for gastroparesis and cachexia.
Mechanism of Action
Binds to growth hormone secretagogue receptor (GHSR) in hypothalamus to stimulate appetite. In the GI tract, it promotes gastric emptying and intestinal motility. Also stimulates growth hormone release from pituitary.
Pharmacokinetics
Short half-life of 10-30 minutes. Levels rise before meals and fall after eating. Acylation required for receptor binding.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Gastroparesis Research
1-5 mcg/kg
Before meals
Variable
Research protocols
Cachexia Research
2-5 mcg/kg
1-2x daily
Weeks
Appetite stimulation
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Accelerates gastric emptying in gastroparesis
- 2Increases appetite and food intake
- 3Improves nutritional status in cachexia
- 4Stimulates GH release
Side Effects & Contraindications
Reported Side Effects
- Increased appetite
- Hunger
- Mild glucose elevation
Contraindications
- Diabetes (use caution)
- Active GI bleeding
Safety Considerations
May increase appetite significantly. Blood glucose effects possible. Research compound for therapeutic use.
Storage Requirements
Store at -20C
Scientific References
- 1