FST 344

Also known as: Follistatin 344, FST-344, Myostatin Inhibitor

A follistatin isoform that inhibits myostatin for muscle growth and strength.

Overview

Follistatin 344 is a glycoprotein that inhibits myostatin and activin, two negative regulators of muscle growth. By blocking these proteins, FST-344 allows for increased muscle mass and strength. It has garnered significant interest in both medical and performance contexts.

Mechanism of Action

Binds to and neutralizes myostatin (GDF-8) and activin A, removing the brakes on muscle growth. This allows increased satellite cell proliferation and muscle protein synthesis. Also affects FSH through activin inhibition.

Pharmacokinetics

Gene therapy or protein delivery approaches studied. Direct protein injection has limited half-life. Gene therapy provides sustained expression.

Dosing Protocols

Note: These are research protocols from literature. This is not medical advice.

1

Research

Dose

100-300 mcg

Frequency

Daily to weekly

Duration

4-8 weeks

Research protocols vary widely

Stacking Recommendations

Peptides that may be combined based on complementary mechanisms in research settings.

Rationale: Muscle growth

Synergy: Remove inhibition plus add stimulation

Research Areas

Muscle WastingMuscular DystrophySarcopeniaAthletic PerformanceMyostatin Inhibition

Key Research Findings

  • 1Potent myostatin inhibitor
  • 2Significant muscle gains in animal studies
  • 3Gene therapy trials for muscle diseases
  • 4Also affects reproductive hormones via activin

Side Effects & Contraindications

Reported Side Effects

  • Potential FSH suppression
  • Unknown long-term effects

Contraindications

  • Reproductive concerns
  • Hormone-sensitive conditions

Safety Considerations

Research compound. May affect reproductive function via activin inhibition. Gene therapy approaches carry typical risks. Limited human safety data.

Storage Requirements

Store at -20C

Scientific References

Quick Reference

Sequence
344 amino acid glycoprotein
Molecular Weight
~38 kDa
Half-Life
Variable by delivery method
Bioavailability
Injectable or gene therapy
Research Stage
clinical phase 2
Administration
Intramuscular or gene therapy