Dermorphin
Also known as: Demorphin, Frog Peptide Opioid
A potent opioid peptide from frog skin with powerful analgesic properties.
Overview
Dermorphin is a seven-amino acid peptide originally isolated from the skin of South American frogs. It is one of the most potent naturally occurring opioid peptides, with 30-40 times the potency of morphine. It has been studied for analgesia but also misused in horse racing.
Mechanism of Action
Highly selective mu-opioid receptor agonist. Contains D-alanine which provides resistance to enzymatic degradation. Produces potent analgesia, euphoria, and respiratory depression like other opioids.
Pharmacokinetics
Enhanced stability due to D-amino acid. Crosses blood-brain barrier. Half-life longer than enkephalins due to protease resistance.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research Only
N/A
N/A
N/A
Not for human therapeutic use - research compound only
Research Areas
Key Research Findings
- 130-40x more potent than morphine
- 2Highly selective for mu-opioid receptors
- 3D-amino acid provides metabolic stability
- 4Banned in horse racing due to performance effects
Side Effects & Contraindications
Reported Side Effects
- Respiratory depression
- Sedation
- Euphoria
- Nausea
- Physical dependence
Contraindications
- Human therapeutic use
- Respiratory conditions
- Opioid sensitivity
Safety Considerations
HIGHLY POTENT OPIOID - extreme caution required. Risk of respiratory depression, addiction, and death. Controlled substance in many jurisdictions. Research use only.
Storage Requirements
Store at -20°C
Scientific References
- 1Dermorphin structure and activity
Montecucchi PC et al.
International Journal of Peptide Research, 1981