ACTH 1-39
Also known as: Adrenocorticotropic Hormone, Corticotropin
The full-length adrenocorticotropic hormone with effects on cortisol, cognition, and stress response.
Overview
ACTH 1-39 is the complete 39-amino acid adrenocorticotropic hormone secreted by the anterior pituitary. It stimulates cortisol production and has documented effects on learning, memory, and attention beyond its endocrine functions.
Mechanism of Action
Binds to melanocortin receptors (MC2R primarily, also MC3R/MC4R). Stimulates adrenal cortex to produce cortisol, aldosterone, and androgens. Central effects on attention and memory via MC4R in hippocampus.
Pharmacokinetics
Very short half-life (~10 minutes). Rapid metabolism by proteases. Subcutaneous or IV administration.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Cognitive Research
0.1-0.5 mg
Single dose studies
Acute
Research protocols only
Medical Use (Infantile Spasms)
150 IU/m²
Daily
2-6 weeks
Under specialist supervision
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Proven treatment for infantile spasms (West syndrome)
- 2Enhanced attention and visual memory in human studies
- 3Improved learning retention in animal models
- 4Neuroprotective effects independent of cortisol
Side Effects & Contraindications
Reported Side Effects
- Elevated cortisol
- Fluid retention
- Hypertension
- Mood changes
- Glucose intolerance
Contraindications
- Cushing's syndrome
- Systemic fungal infections
- Ocular herpes simplex
- Uncontrolled hypertension
Safety Considerations
Can cause significant cortisol elevation. Monitor for Cushing's symptoms. Use only under medical supervision.
Storage Requirements
Refrigerate 2-8°C
Scientific References
- 1