Vapreotide
Also known as: RC-160, Sanvar, Somatostatin Analog
A somatostatin analog used for GI bleeding and variceal hemorrhage.
Overview
Vapreotide is a synthetic octapeptide analog of somatostatin with longer duration of action. It is used primarily for acute esophageal variceal bleeding and has applications in various GI conditions where reduction of splanchnic blood flow is beneficial.
Mechanism of Action
Binds to somatostatin receptors, reducing splanchnic blood flow and portal pressure. Inhibits release of vasodilatory hormones (glucagon, VIP). Reduces GI secretions and motility.
Pharmacokinetics
Half-life approximately 30 minutes, much longer than native somatostatin. Continuous IV infusion or repeated SC dosing.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Variceal Bleeding
250 mcg bolus, then 250 mcg/hr
Continuous infusion
Up to 5 days
Acute management
Research Areas
Key Research Findings
- 1Effective for acute variceal bleeding
- 2Reduces portal pressure
- 3Longer acting than native somatostatin
- 4Used in acute GI hemorrhage
Side Effects & Contraindications
Reported Side Effects
- Hyperglycemia
- Bradycardia
- Nausea
- Injection site pain
Contraindications
- Hypersensitivity to somatostatin analogs
Safety Considerations
Monitor for hyperglycemia, bradycardia. May affect thyroid function with prolonged use.
Storage Requirements
Refrigerate 2-8C
Scientific References
- 1