Temporin A

Temporin A is a 13-amino acid antimicrobial peptide isolated from the European red frog (Rana temporaria). Despite its small size, it demonstrates remarkable antiparasitic activity, particularly against Leishmania species responsible for leishmaniasis, a neglected tropical disease.

Temporin A forms an alpha-helical structure that inserts into parasite membranes. Its small size allows rapid membrane penetration. It targets both the plasma membrane and internal organelle membranes, including mitochondria, leading to apoptosis-like death in parasites.

Small size enables rapid tissue penetration. More resistant to certain proteases than larger AMPs. Can cross biological barriers effectively.

Note: These are research protocols from literature. This is not medical advice.

Peptides that may be combined based on complementary mechanisms in research settings.

• 1Highly effective against Leishmania infantum and L. major promastigotes and amastigotes
• 2IC50 values in low micromolar range against multiple Leishmania species
• 3Induces mitochondrial dysfunction and apoptosis in parasites
• 4Active against drug-resistant Leishmania strains
• 5Synergistic with standard leishmanicidal drugs (amphotericin B, miltefosine)

Store lyophilized at -20°C. Light sensitive.

Scientific References

• 1
  Temporins, antimicrobial peptides from the European red frog with antiparasitic activity

  Mangoni ML, et al.

  Biochimica et Biophysica Acta, 2005

• 2
  Antileishmanial activity of temporin family peptides

  Chadbourne FL, et al.

  Antimicrobial Agents and Chemotherapy, 2011