MGF
Also known as: Mechano Growth Factor, IGF-1Ec
A splice variant of IGF-1 activated by mechanical stress for muscle repair.
Overview
MGF is a splice variant of IGF-1 produced in response to mechanical overload and muscle damage. It activates satellite cells for muscle repair and hypertrophy.
Mechanism of Action
MGF activates muscle satellite cells, promoting their proliferation and differentiation. It works through IGF-1 receptor-independent mechanisms initially, then transitions to IGF-1R signaling for maturation.
Pharmacokinetics
Very short half-life (minutes). PEGylated versions (PEG-MGF) extend duration significantly.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Standard
100-200 mcg
Post-workout
4-6 weeks
Inject into target muscle bilaterally
PEG-MGF
200 mcg
2-3x weekly
4-6 weeks
Systemic administration acceptable
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Rapid satellite cell activation following muscle damage
- 2Enhanced muscle repair in animal models
- 3Cardiac protection in ischemia models
- 4Distinct from systemic IGF-1 in mechanism
Side Effects & Contraindications
Reported Side Effects
- Injection site pain
- Hypoglycemia (rare)
Contraindications
- Active cancer
- Pregnancy
Safety Considerations
Limited human data. Theoretical IGF-related concerns.
Storage Requirements
Store lyophilized at -20C
Scientific References
- 1