Hexarelin Acetate
Also known as: Hexarelin, Examorelin, HEX
A potent growth hormone secretagogue with strong GH release and cardioprotective effects.
Overview
Hexarelin is a synthetic hexapeptide growth hormone releasing peptide (GHRP) that strongly stimulates GH release. It is one of the most potent GHRPs available but causes significant desensitization with continuous use. It also has notable cardioprotective effects independent of GH release.
Mechanism of Action
Agonist at ghrelin/GHSR receptors in pituitary and hypothalamus. Stimulates GH release via multiple mechanisms. Also binds cardiac receptors providing cardioprotection. Increases cortisol and prolactin more than other GHRPs.
Pharmacokinetics
Half-life 60-70 minutes. Subcutaneous or IV administration. Peak GH at 30-60 minutes.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
GH Release
100-200 mcg
1-3x daily
2-4 weeks on, 2-4 weeks off
Must cycle due to desensitization
Cardiac Research
100-200 mcg
2x daily
Variable
Cardioprotective doses
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Strongest GH release of all GHRPs
- 2Significant desensitization occurs within 2 weeks
- 3Cardioprotective effects independent of GH
- 4Increases cortisol and prolactin
Side Effects & Contraindications
Reported Side Effects
- Hunger increase
- Cortisol elevation
- Prolactin elevation
- Water retention
- Tingling/numbness
Contraindications
- Continuous use (desensitization)
- Prolactin-sensitive conditions
Safety Considerations
Research compound. Causes more prolactin/cortisol elevation than Ipamorelin. Desensitizes quickly - requires cycling. Not for continuous use.
Storage Requirements
Refrigerate 2-8°C after reconstitution
Scientific References
- 1