Benzyl Alcohol
Also known as: BA, 0.9% Benzyl Alcohol, Preservative Solution
A preservative solution used in bacteriostatic water and some peptide formulations.
Overview
Benzyl alcohol is an aromatic alcohol used as a bacteriostatic preservative in multi-dose vials. At 0.9% concentration (as in bacteriostatic water), it prevents microbial growth without killing existing organisms. It is also used as a solvent in some injectable formulations.
Mechanism of Action
Inhibits bacterial reproduction by disrupting membrane function. Does not sterilize but prevents growth. At low concentrations, provides preservation without significant tissue irritation.
Pharmacokinetics
Rapidly metabolized to benzoic acid, then conjugated with glycine to form hippuric acid for renal excretion.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
As Preservative
0.9% in solution
N/A
N/A
Standard bacteriostatic concentration
Research Areas
Key Research Findings
- 1Standard preservative at 0.9% concentration
- 2Enables multi-dose vial use
- 3Metabolized to benzoic acid
- 4Generally well-tolerated in adults
Side Effects & Contraindications
Reported Side Effects
- Injection site irritation
- Allergic reaction (rare)
Contraindications
- Neonates
- Infants
- Hypersensitivity
Safety Considerations
Toxic to neonates (gasping syndrome). Do not use in infants. Safe for adults at standard concentrations.
Storage Requirements
Room temperature
Scientific References
- 1