5-Amino-1MQ
Also known as: 5-amino-1-methylquinolinium
A small molecule NNMT inhibitor studied for metabolic regulation and fat cell metabolism.
Overview
5-Amino-1MQ is a membrane-permeable small molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that regulates cellular energy expenditure.
Mechanism of Action
Inhibits NNMT enzyme, leading to increased NAD+ levels and enhanced SIRT1 activity. This promotes fat cell shrinkage, increased energy expenditure, and improved metabolic function.
Pharmacokinetics
Oral bioavailability allows for oral administration. Rapid tissue distribution with preferential accumulation in adipose tissue.
Dosing Protocols
Note: These are research protocols from literature. This is not medical advice.
Research Protocol
50-100 mg
Once daily
4-8 weeks
Based on preclinical data extrapolation
Stacking Recommendations
Peptides that may be combined based on complementary mechanisms in research settings.
Research Areas
Key Research Findings
- 1Preclinical studies show reduced fat mass without affecting food intake
- 2Reverses diet-induced obesity in mouse models
- 3Increases whole-body energy expenditure
- 4Improves glucose tolerance and insulin sensitivity
Side Effects & Contraindications
Reported Side Effects
- Limited data available
Contraindications
- Pregnancy
- Liver disease
Safety Considerations
Limited human safety data. Preclinical studies suggest good tolerability.
Storage Requirements
Store at room temperature, protected from light
Scientific References
- 1NNMT inhibition as an anti-obesity therapeutic approach
Neelakantan H, et al.
Biochemical Pharmacology, 2017